hallo Forum,
mal wieder was Neues zum Thema Fischöl, aber in Kombination mit Vitamin D und PK, dankenswerterweise von Dr.Eichhorn geschickt, leider gibts nur einen Abstract, s.u.:
Die Autoren aus Boston kommen zum Schluss:
"Based on these results, we hypothesize that dietary components, such as omega3PUFAs and Vitamin D, have the potential to delay the progression of prostate cancer cells to an aggressive and un-treatable state."
Basierend auf diesen Ergebnissen stellen wir die Hypothese auf, dass Nahrungsbestandteile wie mehrfach ungesättigte Omega-3-Fettsäuren und Vitamin D das Potential haben, den Progress von Prostatakrebszellen hin zu einem aggressiven und unbehandelbaren Zustand zu verzögern.
So it seems to be.
Grüsse,
Rudolf
++++++++++++++++++++++
1: J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):726-30. Epub 2007 Jan 12.
1alpha,25-Dihydroxyvitamin D and fish oil synergistically inhibit G1/S-phase transition in prostate cancer cells.
Istfan NW, Person KS, Holick MF, Chen TC.
Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. naistfan@bmc.org
Laboratory and epidemiological studies have indicated that 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] and dietary omega3-polyunsaturated fatty acids (PUFAs) are capable of inhibiting prostate cancer at the initiation and progression stages.
The objective of this study is to investigate the influence of 1alpha,25(OH)(2)D(3) and PUFAs in the form of fish oil applied alone or in combination on cell cycle kinetics in the exponentially growing androgen-dependent and -independent prostate cancer cells.
Our data indicate that the high passage androgen-independent cell line, LNCaP-c115 had a much greater inhibitory response at the level of the G(1)/S-phase transition in response to fish oil treatment than androgen-dependent low passage LNCaP-c38 cells.
When LNCaP-c38 and LNCaP-c115 cells were treated with fish oil (50mug/ml), 1alpha,25(OH)(2)D(3) (10(-8)M)
or fish oil (50mug/ml)+1alpha,25(OH)(2)D(3) (10(-8)M),
a synergistic growth inhibitory effect was observed with 1alpha,25(OH)(2)D(3)+fish oil group in LNCaP-c115 cell line at the levels of the G(1)/S-phase transition and cell division.
This interaction appears to be specific for androgen-independent prostate cancer cell lines.
Based on these results, we hypothesize that dietary components, such as omega3PUFAs and Vitamin D, have the potential to delay the progression of prostate cancer cells to an aggressive and un-treatable state.
PMID: 17223546 [PubMed - indexed for MEDLINE]
++++++++
wer besorgt den volltext?
wer fragt bei sears oder den o.a. doctores mal nach, was die anderen studien mit fischöl + pk so machen?
wer erklärt, was da mit vitamin d + fischöl genau passiert?
und vielleicht: wer schafft die verbindung des cholesterin-abkömmlings vitamin D, das ebenso wie die anderen abkömmlinge als fettlösliche hormone durch die membranen durchdiffundieren und im zellkern entsprechende rezeptoren finden, zu den sexualhormonen und mal so ein gemeinsames bild der wirkung auf p- und pk-zellen? (das letztere könnte doch für irgendjemand ne diplomarbeit werden ..? )
mal wieder was Neues zum Thema Fischöl, aber in Kombination mit Vitamin D und PK, dankenswerterweise von Dr.Eichhorn geschickt, leider gibts nur einen Abstract, s.u.:
Die Autoren aus Boston kommen zum Schluss:
"Based on these results, we hypothesize that dietary components, such as omega3PUFAs and Vitamin D, have the potential to delay the progression of prostate cancer cells to an aggressive and un-treatable state."
Basierend auf diesen Ergebnissen stellen wir die Hypothese auf, dass Nahrungsbestandteile wie mehrfach ungesättigte Omega-3-Fettsäuren und Vitamin D das Potential haben, den Progress von Prostatakrebszellen hin zu einem aggressiven und unbehandelbaren Zustand zu verzögern.
So it seems to be.
Grüsse,
Rudolf
++++++++++++++++++++++
1: J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):726-30. Epub 2007 Jan 12.
1alpha,25-Dihydroxyvitamin D and fish oil synergistically inhibit G1/S-phase transition in prostate cancer cells.
Istfan NW, Person KS, Holick MF, Chen TC.
Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. naistfan@bmc.org
Laboratory and epidemiological studies have indicated that 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] and dietary omega3-polyunsaturated fatty acids (PUFAs) are capable of inhibiting prostate cancer at the initiation and progression stages.
The objective of this study is to investigate the influence of 1alpha,25(OH)(2)D(3) and PUFAs in the form of fish oil applied alone or in combination on cell cycle kinetics in the exponentially growing androgen-dependent and -independent prostate cancer cells.
Our data indicate that the high passage androgen-independent cell line, LNCaP-c115 had a much greater inhibitory response at the level of the G(1)/S-phase transition in response to fish oil treatment than androgen-dependent low passage LNCaP-c38 cells.
When LNCaP-c38 and LNCaP-c115 cells were treated with fish oil (50mug/ml), 1alpha,25(OH)(2)D(3) (10(-8)M)
or fish oil (50mug/ml)+1alpha,25(OH)(2)D(3) (10(-8)M),
a synergistic growth inhibitory effect was observed with 1alpha,25(OH)(2)D(3)+fish oil group in LNCaP-c115 cell line at the levels of the G(1)/S-phase transition and cell division.
This interaction appears to be specific for androgen-independent prostate cancer cell lines.
Based on these results, we hypothesize that dietary components, such as omega3PUFAs and Vitamin D, have the potential to delay the progression of prostate cancer cells to an aggressive and un-treatable state.
PMID: 17223546 [PubMed - indexed for MEDLINE]
++++++++
wer besorgt den volltext?
wer fragt bei sears oder den o.a. doctores mal nach, was die anderen studien mit fischöl + pk so machen?
wer erklärt, was da mit vitamin d + fischöl genau passiert?
und vielleicht: wer schafft die verbindung des cholesterin-abkömmlings vitamin D, das ebenso wie die anderen abkömmlinge als fettlösliche hormone durch die membranen durchdiffundieren und im zellkern entsprechende rezeptoren finden, zu den sexualhormonen und mal so ein gemeinsames bild der wirkung auf p- und pk-zellen? (das letztere könnte doch für irgendjemand ne diplomarbeit werden ..? )
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